Paget’s Disease of Breast

Paget’s disease of the breast is a rare type of breast cancer that affects the skin and underlying ducts of the nipple and areola. It is named after Sir James Paget, a British surgeon who first described the condition in 1874. Paget’s disease of the breast typically occurs in women, although men can also be affected.

The exact cause of Paget’s disease of the breast is still unknown, but it is believed to be associated with underlying ductal breast cancer. The cancer cells from the underlying ducts migrate to the surface of the nipple and areola, resulting in the characteristic symptoms and visual changes.

The most common symptom of Paget’s disease of the breast is a persistent, scaly, red rash on the nipple and areola. The rash may cause itching, burning, or flaking of the skin. Additionally, women may experience nipple discharge, nipple inversion, and sometimes a lump in the breast.

Diagnosing Paget’s disease of the breast involves a combination of physical examination, mammography, breast ultrasound, and a biopsy of the affected area. The biopsy helps confirm the presence of cancer cells in the skin.

Treatment for Paget’s disease of the breast often involves a combination of surgery and radiation therapy. The primary goal is to remove the cancerous tissue while preserving as much of the breast as possible. In some cases, a mastectomy (removal of the entire breast) may be necessary.

Following surgery, additional treatments such as chemotherapy, hormone therapy, or targeted therapy may be recommended based on the underlying characteristics of the cancer.

The prognosis for Paget’s disease of the breast varies depending on factors such as the stage of the underlying breast cancer and the presence of any lymph node involvement. Early detection and prompt treatment can improve the chances of successful outcomes.

Regular breast self-examinations, mammograms, and clinical breast exams are essential for detecting any changes or abnormalities in the breast. If you notice any persistent skin changes on the nipple or areola, nipple discharge, or other unusual breast symptoms, it is important to consult a healthcare professional for evaluation.